Tdp2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Tyrosyl-DNA Phosphodiesterase 2 | |
|---|---|
| Protein Name | TDP2 |
| UniProt ID | [Q9H2P2](https://www.uniprot.org/uniprot/Q9H2P2) |
| Alternative Names | TTRAP, Eukaryotic DNA Topoisomerase II-Associated Protein |
| Gene Symbol | [TDP2](/genes/tdp2) |
| Protein Type | DNA Repair Enzyme |
| Molecular Weight | ~60 kDa |
| Subcellular Location | Nucleus, Cytoplasm |
TDP2 (Tyrosyl-DNA Phosphodiesterase 2) is a DNA repair enzyme that specifically removes topoisomerase II (TOP2) covalent complexes from DNA. It plays a critical role in maintaining genomic stability and protecting cells from genotoxic stress.
TDP2 contains:
The protein adopts a fold typical of the metallo-hydrolase family.
TDP2 resolves TOP2-DNA covalent complexes (TOP2cc):
TDP2 maintains genome integrity by:
TDP2 can function as a transcriptional co-regulator:
In neurons, TDP2 protects against:
Some TDP2 variants cause cerebellar ataxia:
TDP2 is a target for:
The study of Tdp2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.