Tdp2 — Tyrosyl Dna Phosphodiesterase 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Tyrosyl-DNA Phosphodiesterase 2 | |
|---|---|
| Gene Symbol | TDP2 |
| Full Name | tyrosyl-DNA phosphodiesterase 2 |
| Chromosome | 6p22.3 |
| NCBI Gene ID | 51567 |
| OMIM | 614675 |
| Ensembl ID | ENSG00000111802 |
| UniProt ID | Q9H2P2 |
| Associated Diseases | Amyotrophic Lateral Sclerosis, Parkinson's Disease, Ataxia |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
TDP2 (Tyrosyl-DNA Phosphodiesterase 2), also known as TTRAP, is a DNA repair enzyme that specifically removes topoisomerase II-mediated DNA adducts. It plays crucial roles in:
TDP2 is expressed in:
The study of Tdp2 — Tyrosyl Dna Phosphodiesterase 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.