Synaptopodin (Synpo Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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SYNPO Protein
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Protein Name: Synaptopodin
Gene: SYNPO
UniProt ID: Q9Y7X6
Molecular Weight: 100 kDa
Protein Family: Synaptopodin family
Subcellular Localization: Dendritic spines, spine apparatus
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Synaptopodin is a protein encoded by the SYNPO gene. It belongs to the Synaptopodin family and is primarily localized to Dendritic spines, spine apparatus.
SYNPO is a 100 kDa protein with multiple domains that enable its functions in neuronal development and synaptic communication.
Actin-associated protein, spine apparatus formation, synaptic plasticity, memory. This protein plays critical roles in brain development and function.
Alterations in SYNPO have been associated with several neurological and neurodevelopmental disorders. The protein's role in synaptic function makes it relevant to understanding neurodegenerative processes.
Research is ongoing to develop therapeutic approaches targeting SYNPO.
[1] https://pubmed.ncbi.nlm.nih.gov/9182613/
[2] https://pubmed.ncbi.nlm.nih.gov/10574462/
[3] https://pubmed.ncbi.nlm.nih.gov/11891228/
[4] https://pubmed.ncbi.nlm.nih.gov/15231748/
[5] https://pubmed.ncbi.nlm.nih.gov/16033772/
Synaptopodin is essential for the spine apparatus, a specialized organelle:
The study of Synaptopodin (Synpo Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.