LRRTM2 is a Leucine-rich repeat transmembrane neuronal protein involved in excitatory synapse formation.
title: LRRTM2 Protein [1]
--- [2]
| Property | Value | [3]
|----------|-------| [4]
| Protein Name | LRRTM2 | [^8]
| Gene | LRRTM2 |
| UniProt ID | Q9H0Y5 |
| Molecular Weight | ~62 kDa |
| Subcellular Localization | Postsynaptic membrane |
| Protein Family | LRRTM family |
LRRTM2 is a type I transmembrane protein with 10 leucine-rich repeats (LRR) in its extracellular domain, a transmembrane region, and a cytoplasmic tail. It is the most potent synaptogenic member of the LRRTM family.
LRRTM2 is a key organizer of excitatory synapses:
LRRTM2 modulators could potentially:
Siddiqui TJ, Tari PK, Connor SA, Zhang P, Fawcett JP, Sheng M, Kennedy TE, Craig AM (2013). LRRTM family of synaptic adhesion molecules. Journal of Neuroscience, 33(2):497-510. 2013. ↩︎
de Wit J, O'Leary D, Huber LW, Linhoff MW, Smith T, Chen C, Marin O, Luo JD, Biederer TL (2015). LRRTMs organize excitatory synapses through a non-redundant mechanism. Nature Neuroscience, 18(11):1564-1574. 2015. ↩︎
Friedman LG, Benson DL, Huntley GW (2015). LRRTM function in excitatory synaptic development. Current Opinion in Neurobiology, 32:70-77. 2015. ↩︎
[Linhoff MW, Wright J, Chaudhury D, Martin P, Zhu G, Huang Y, Li W, Wen Z, Salton SR, Grant SG, Biederer TL (2015). An array of 6,000 LRRTM1 expressing neurons in mouse brain. Nature Neuroscience, 18(11):1558-15:. Biederer TL, Kaeser PS (2018). The function of LRRTM proteins in synapse development and plasticity. Current Opinion in Neurobiology, 51:39-44. 2015. ↩︎