LRRTM3 is a Leucine-rich repeat transmembrane neuronal protein involved in synaptic organization.
title: LRRTM3 Protein [1]
--- [2]
| Property | Value | [3]
|----------|-------| [4]
| Protein Name | LRRTM3 | [5]
| Gene | LRRTM3 |
| UniProt ID | Q86VH5 |
| Molecular Weight | ~65 kDa |
| Subcellular Localization | Postsynaptic membrane |
| Protein Family | LRRTM family |
LRRTM3 contains the characteristic LRRTM domain architecture: an N-terminal signal peptide, 10 leucine-rich repeats, a transmembrane domain, and a C-terminal cytoplasmic tail. It has distinct binding properties from other LRRTMs.
LRRTM3 has specialized synaptic functions:
Last et al. Ataxin-2 function and disease (2020). 2020. ↩︎
Gispert-Sanchez et al. ATXN2 and RNA granules (2015). 2015. ↩︎
Nonis et al. ATXN2 in diabetes (2022). 2022. ↩︎
Kumar et al. ATXN2 therapeutic targeting (2021). 2021. ↩︎