LRRTM3 is a Leucine-rich repeat transmembrane neuronal protein involved in synaptic organization.
| Property |
Value |
| Protein Name |
LRRTM3 |
| Gene |
LRRTM3 |
| UniProt ID |
Q86VH5 |
| Molecular Weight |
~65 kDa |
| Subcellular Localization |
Postsynaptic membrane |
| Protein Family |
LRRTM family |
LRRTM3 contains the characteristic LRRTM domain architecture: an N-terminal signal peptide, 10 leucine-rich repeats, a transmembrane domain, and a C-terminal cytoplasmic tail. It has distinct binding properties from other LRRTMs.
LRRTM3 has specialized synaptic functions:
- Excitatory Synapse Formation: Promotes excitatory synapse development
- Visual Circuit Development: Critical for retinogeniculate synapse formation
- AMPAR Regulation: Modulates AMPA receptor function
- Learning and Memory: Involved in hippocampal-dependent learning
- Genetic variants associated with AD risk
- Synaptic function altered in AD
- Rare variants found in ASD
- Possible synaptic mechanism
- Soler-Llavina et al., LRRTM family function (2013)
- Dickel et al., LRRTM3 in visual system (2014)
- Pulst et al., SCA2 identification (1996)
- Elden et al., ATXN2 expansions in ALS (2010)
- Bhattacharjee et ATXN2 in RNA metabolism (2011)
- Last et al., Ataxin-2 function and disease (2020)
- Sato et al., ATXN2 in Parkinson's disease (2019)
- Gispert-Sanchez et al., ATXN2 and RNA granules (2015)
- Nonis et al., ATXN2 in diabetes (2022)
- Kumar et al., ATXN2 therapeutic targeting (2021)