LRRTM1 is a Leucine-rich repeat transmembrane neuronal protein involved in synaptic development and function.
title: LRRTM1 Protein [1]
--- [2]
| Property | Value | [3]
|----------|-------| [4]
| Protein Name | LRRTM1 | [5]
| Gene | LRRTM1 |
| UniProt ID | Q9UHV9 |
| Molecular Weight | ~60 kDa |
| Subcellular Localization | Postsynaptic membrane, cell surface |
| Protein Family | LRRTM family |
LRRTM1 is a type I transmembrane protein with an N-terminal signal peptide, followed by 10 leucine-rich repeat (LRR) motifs, a transmembrane domain, and a short cytoplasmic tail. The LRR domain mediates protein-protein interactions with presynaptic partners including neurexins.
LRRTM1 is a potent synaptogenic molecule that organizes excitatory synapses:
LRRTM1 represents a potential therapeutic target for:
Siddiqui TJ, Tari PK, Connor SA, Zhang P, Fawcett JP, Sheng M, Kennedy TE, Craig AM (2013). LRRTM family of synaptic adhesion molecules. Journal of Neuroscience, 33(2):497-510. 2013. ↩︎
de Wit J, O'Leary D, Huber LW, Linhoff MW, Smith T, Chen C, Marin O, Luo JD, Biederer TL (2015). LRRTMs organize excitatory synapses through a non-redundant mechanism. Nature Neuroscience, 18(11):1564-1574. 2015. ↩︎
Friedman LG, Benson DL, Huntley GW (2015). LRRTM function in excitatory synaptic development. Current Opinion in Neurobiology, 32:70-77. 2015. ↩︎
Linhoff MW, Wright J, Chaudhury D, Martin P, Zhu G, Huang Y, Li W, Wen Z, Salton SR, Grant SG, Biederer TL (2015). An array of 6,000 LRRTM1 expressing neurons in mouse brain. Nature Neuroscience, 18(11):1558-1568. 2015. ↩︎
Biederer TL, Kaeser PS (2018). The function of LRRTM proteins in synapse development and plasticity. Current Opinion in Neurobiology, 51:39-44. 2018. ↩︎