Lin 7 Homolog A (Veli 1) (Lin7A Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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LIN7A Protein
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Protein Name: Lin-7 Homolog A (Veli-1)
Gene: LIN7A
UniProt ID: O75774
Molecular Weight: 23 kDa
Protein Family: LIN7 family
Subcellular Localization: Synaptic membranes
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Lin-7 Homolog A (Veli-1) is a protein encoded by the LIN7A gene. It belongs to the LIN7 family and is primarily localized to Synaptic membranes.
LIN7A is a 23 kDa protein with multiple domains that enable its scaffolding and signaling functions in neurons.
Membrane protein targeting, synaptic scaffolding. This protein plays important roles in maintaining normal neuronal function and synaptic transmission.
Alterations in LIN7A have been associated with several neurodegenerative and neurological disorders. Studies have shown changes in expression and mutations in various disease contexts.
Research is ongoing to develop therapeutic approaches targeting LIN7A for neurological disorders.
[1] https://pubmed.ncbi.nlm.nih.gov/10574462/
[2] https://pubmed.ncbi.nlm.nih.gov/10893236/
[3] https://pubmed.ncbi.nlm.nih.gov/11891228/
[4] https://pubmed.ncbi.nlm.nih.gov/15231748/
[5] https://pubmed.ncbi.nlm.nih.gov/19139271/
LIN7 proteins (Veli/MALS) are critical for targeting proteins to postsynaptic sites:
The study of Lin 7 Homolog A (Veli 1) (Lin7A Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.