Kif21B Protein (Kinesin Family Member 21B) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-protein
| KIF21B Protein (Kinesin Family Member 21B) | |
|---|---|
| Gene | KIF21B |
| UniProt | Q9UMW8 |
| Molecular Weight | ~180 kDa |
| Subcellular Localization | Cytoplasm, neuronal processes |
| Protein Family | Kinesin family |
| Aliases | KIF21B |
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KIF21B is a member of the kinesin family of motor proteins. It is a plus-end-directed motor protein that walks along microtubules. The protein contains an N-terminal motor domain, coiled-coil regions for dimerization, and a C-terminal cargo-binding domain.
KIF21B regulates neuronal transport:
KIF21B dysfunction contributes to AD:
KIF21B variants are associated with MS risk:
KIF21B mutations cause neurodevelopmental disorders with intellectual disability.
KIF21B modulators are being explored for:
The study of Kif21B Protein (Kinesin Family Member 21B) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The KIF21B Protein is a protein involved in various cellular processes in the nervous system. This protein plays important roles in neuronal function, signal transduction, and cellular homeostasis. Dysfunction of this protein has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The KIF21B Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, membrane potential regulation, and intracellular signaling cascades.
Alterations in KIF21B Protein expression or function have been associated with several neurodegenerative conditions. Research suggests that this protein may serve as a therapeutic target for disease modification in AD, PD, and related disorders.