Homer Scaffold Protein 1 (Homer1 Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@xiao2000]
title: HOMER1 Protein [@sala2001]
description: Homer Scaffold Protein 1 - mGluR scaffolding, synaptic plasticity, calcium signaling regulation [@pmidhttp]
tags: protein, neurodegeneration, Homer family [^5]
.infobox.inbox-protein [@homer]
HOMER1 Protein [@homera]
=== ===
Protein Name: Homer Scaffold Protein 1
Gene: HOMER1
UniProt ID: Q86YM7
Molecular Weight: 186 kDa
Protein Family: Homer family
Subcellular Localization: Postsynaptic densities
=== ===
Homer Scaffold Protein 1 is a protein encoded by the HOMER1 gene. It belongs to the Homer family and is primarily localized to Postsynaptic densities.
HOMER1 is a 186 kDa protein with multiple domains that enable its scaffolding and signaling functions in neurons.
mGluR scaffolding, synaptic plasticity, calcium signaling regulation. This protein plays important roles in maintaining normal neuronal function and synaptic transmission.
Alterations in HOMER1 have been associated with several neurodegenerative and neurological disorders. Studies have shown changes in expression and mutations in various disease contexts.
Research is ongoing to develop therapeutic approaches targeting HOMER1 for neurological disorders.
[1] https://pubmed.ncbi.nlm.nih.gov/10574462/
[2] https://pubmed.ncbi.nlm.nih.gov/10893236/
[3] https://pubmed.ncbi.nlm.nih.gov/11891228/
[4] https://pubmed.ncbi.nlm.nih.gov/15231748/
[5] https://pubmed.ncbi.nlm.nih.gov/19139271/
Homer proteins are key effectors of group I metabotropic glutamate receptors (mGluR1/5):
The study of Homer Scaffold Protein 1 (Homer1 Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
PMID:11891228
PMID:22926526 - Homer mutations in neurodevelopmental disorders
[@homer]: PMID:26168996 - Homer scaffolding in neurodegenerative diseases
[@homera]: PMID:38000303 - Homer1 in synaptic organization and neurological disorders