Gabra2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value | [1]
|----------|-------| [2]
| Protein Name | GABA-A Receptor Alpha2 Subunit | [3]
| Gene | GABRA2 | [4]
| UniProt ID | P47869 | [5]
| PDB ID | 5EW7, 6HUP | [6]
| Molecular Weight | 51 kDa | [7]
| Subcellular Localization | Plasma membrane (synaptic and extrasynaptic) |
| Protein Family | Cys-loop ligand-gated ion channel receptor family |
The GABA-A receptor alpha2 subunit shares the general architecture of Cys-loop ligand-gated ion channels:
Alpha2-containing receptors typically have the composition α2β2/3γ2.
| Drug | Type | Clinical Use |
|---|---|---|
| Baclofen | GABA-B agonist | Alcohol use disorder (off-label) |
| LSA | GABA-A positive allosteric modulator | Research |
The study of Gabra2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
GABRA2 (GABA-A Receptor Alpha 2 Subunit) is a ligand-gated chloride channel subunit:
GABA-A α2 receptors mediate:
Möhler H. (2006). GABA(A) receptors in central nervous system disease. 2006. ↩︎
Rudolph U, et al. (2001). GABA(A) receptor subtypes. 2001. ↩︎
Sieghart W. (2006). Structure, pharmacology and function of GABA(A) receptor subtypes. 2006. ↩︎
Porjesz B, et al. (2002). Linkage disequilibrium between the beta frequency of the human EEG and a GABRA2 gene polymorphism. 2002. ↩︎
Fehr C, et al. (2006). GABRA2 and alcohol dependence. 2006. ↩︎
Bmaie J, et al. (2008). GABA(A) receptor alpha2 subunit. 2008. ↩︎
Whiting PJ. (2003). GABA-A receptor subtypes. 2003. ↩︎