Gabra1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value | [1]
|----------|-------| [2]
| Protein Name | GABA-A Receptor Alpha1 Subunit | [3]
| Gene | GABRA1 | [4]
| UniProt ID | P14867 | [5]
| PDB ID | 1DW6, 5OSM | [6]
| Molecular Weight | 51 kDa | [7]
| Subcellular Localization | Plasma membrane (synaptic and extrasynaptic) |
| Protein Family | Cys-loop ligand-gated ion channel receptor family |
The GABA-A receptor alpha1 subunit is a member of the Cys-loop ligand-gated ion channel family. Each subunit consists of:
The receptor is a heteromeric assembly of five subunits (typically 2α, 2β, 1γ or δ) forming a chloride channel.
| Drug | Type | Clinical Use |
|---|---|---|
| Diazepam | Positive allosteric modulator | Anxiety, sedation, anticonvulsant |
| Lorazepam | Positive allosteric modulator | Sedation, anticonvulsant |
| Zolpidem | Selective agonist | Insomnia |
| Phenobarbital | Allosteric modulator | Anticonvulsant |
| Drug | Type | Clinical Use |
|---|---|---|
| Flumazenil | Competitive antagonist | Benzodiazepine reversal |
The study of Gabra1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Rudolph U, et al. (2001). GABA(A) receptor subtypes: novel drug discovery opportunities. 2001. ↩︎
Möhler H. (2006). GABA(A) receptors in central nervous system disease. 2006. ↩︎
Macdonald RL, et al. (2010). GABA receptor mutations and epilepsy. 2010. ↩︎
Sieghart W. (2006). Structure, pharmacology and function of GABA(A) receptor subtypes. 2006. ↩︎
Whiting PJ. (2003). GABA-A receptor subtypes: function and pharmacology. 2003. ↩︎
Korpi ER, et al. (2002). GABA(A) receptor subunits: beyond the alpha/beta/gamma nomenclature. 2002. ↩︎
Luscher B, et al. (2011). GABA(A) receptor structure and function in the basal ganglia. 2011. ↩︎