Ccl4 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CCL4 (Chemokine C-C Motif Ligand 4), also known as MIP-1β (Macrophage Inflammatory Protein-1 beta), is a CC chemokine that mediates inflammation and immune cell recruitment. It plays important roles in neuroinflammation associated with neurodegenerative diseases. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Protein Name | Chemokine C-C Motif Ligand 4 | [4]
| UniProt ID | Q14139 |
| Gene Symbol | CCL4 |
| Protein Length | 92 amino acids (precursor), 69 aa (mature) |
| Molecular Weight | ~10 kDa |
| Secreted | Yes |
| Also Known As | MIP-1β, ACT-2, LAG-1 |
CCL4 primarily binds to CCR5 and CCR8 receptors to recruit immune cells.
| Receptor | Affinity | Primary Cell Type |
|---|---|---|
| CCR5 | High | Macrophages, memory T cells, microglia |
| CCR8 | Moderate | Th2 cells, regulatory T cells |
| Approach | Description | Status |
|---|---|---|
| CCR5 antagonists | Maraviroc (approved for HIV) | Clinical trials for neurodegeneration |
| CCL4 neutralizing antibodies | Block CCL4 activity | Preclinical |
| Broad-spectrum modulators | Inhibit multiple chemokines | Preclinical |
The study of Ccl4 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.