Ccl3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CCL3 (Chemokine C-C Motif Ligand 3), also known as MIP-1α (Macrophage Inflammatory Protein-1 alpha), is a CC chemokine that plays critical roles in inflammation and immune cell recruitment. It is a key mediator of neuroinflammation in neurodegenerative diseases. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Protein Name | Chemokine C-C Motif Ligand 3 | [4]
| UniProt ID | P10147 |
| Gene Symbol | CCL3 |
| Protein Length | 99 amino acids (precursor), 69 aa (mature) |
| Molecular Weight | ~10 kDa |
| Secreted | Yes |
| Also Known As | MIP-1α, LD78β, G0S19-1 |
CCL3 binds to CCR1, CCR4, and CCR5 receptors to recruit immune cells to sites of inflammation.
| Receptor | Affinity | Primary Cell Type |
|---|---|---|
| CCR1 | High | Monocytes, neutrophils, T cells |
| CCR4 | Moderate | Th2 cells, platelets |
| CCR5 | High | Macrophages, memory T cells |
| Approach | Description | Status |
|---|---|---|
| CCL3 neutralizing antibodies | Block CCL3 activity | Preclinical |
| CCR1 antagonists | Block receptor signaling | Clinical trials |
| CCR5 antagonists | Already in use for HIV | Repurposing potential |
| Small molecule inhibitors | Inhibit CCL3 production | Preclinical |
The study of Ccl3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.