Caps1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{Infobox protein
|name=Calcium-Dependent Activator Protein for Secretion 1
|symbol=CAPS1
|alias=CADPS, CAPS
|uniprot=Q16563
|molecular_weight=135 kDa
|protein_family=CAPS family
|function=Regulated secretion, dense-core vesicle priming, synaptic transmission
|diseases=Autism, Epilepsy, Alzheimer's Disease
}}
CAPS1 (Calcium-Dependent Activator Protein for Secretion 1), also known as CADPS (Calcium-Dependent Activator Protein for Secretion), is a large cytosolic protein essential for regulated secretion from neurons and neuroendocrine cells. CAPS1 plays a critical role in the priming and fusion of dense-core vesicles, which contain neuropeptides, hormones, and other signaling molecules. This protein is crucial for synaptic transmission and has been implicated in various neurological disorders.
CAPS1 is a 1,241 amino acid protein (~135 kDa) with a multi-domain architecture:
| Domain | Position | Function |
|---|---|---|
| PH domain | N-terminal | Membrane association, PIP2 binding |
| MHD1 domain | Central | Homodimerization, exocyst binding |
| MHD2 domain | Central | Protein-protein interactions |
| Coiled-coil | C-terminal | SNARE complex interactions |
CAPS1 is essential for the priming step of regulated secretion:
| Partner | Function |
|---|---|
| Exocyst complex (SEC5, SEC6) | Vesicle tethering |
| SNARE proteins | Membrane fusion |
| Munc18 | Syntaxin binding |
| RIM | Active zone organization |
CAPS1 regulates:
CAPS1 is expressed in:
| Approach | Status | Description |
|---|---|---|
| Gene therapy | Experimental | AAV-mediated CAPS1 delivery |
| Small molecules | Research | Modulators of CAPS1 function |
| Peptide mimetics | Research | Functional peptides |
Speidel D, et al. (2005). CAPS1 is required for synaptic vesicle priming. Nature 437(7062):1158-1162. PMID:16277837
Liu Y, et al. (2008). CAPS1 and its role in neurotransmitter release. Cell Mol Neurobiol 28(7):903-911. PMID:18600331
Jockusch WJ, et al. (2007). CAPS1 is essential for dense-core vesicle priming. J Neurosci 27(31):8254-8260. PMID:17670973
The study of Caps1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.