Calbindin Calbindin D 28K is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
| Calbindin D-28k | |
|---|---|
| Protein Name | Calbindin |
| Gene | CALB1 |
| UniProt ID | P05937 |
| PDB ID | 1IG5 |
| Molecular Weight | 30 kDa |
| Localization | Cytosol |
| Protein Family | EF-hand calcium-binding proteins |
Calbindin D-28k (encoded by the CALB1 gene) is a calcium-binding protein of the EF-hand family with a molecular weight of approximately 30 kDa. It is widely expressed in neurons throughout the central nervous system, particularly in Purkinje cells of the cerebellum, hippocampal pyramidal neurons, and various cortical neuronal populations.
Calbindin serves as a high-affinity calcium buffer, protecting neurons from calcium overload and excitotoxicity. It is one of the most studied calcium-binding proteins in the context of neurodegeneration.
Calbindin D-28k possesses:
Calbindin functions as a neuroprotective calcium buffer:
Calbindin provides neuroprotection through:
Calbindin modulates synaptic function:
Calbindin D-28k has been extensively studied in Alzheimer's disease:
Early Marker: Loss of calbindin is an early marker of neuronal dysfunction
Selective Vulnerability: Calbindin+ neurons show relative resistance to amyloid-beta toxicity
Mechanisms of Protection:
Therapeutic Interest: Calbindin restoration is a potential therapeutic strategy
Calbindin alterations in Huntington's disease:
Calbindin has significant therapeutic potential:
Calbindin is widely used as a neuronal marker:
Calbindin interacts with:
The study of Calbindin Calbindin D 28K has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
German et al. [(1992). Calbindin in substantia nigra. Exp Neurol](https://doi.org/10.1016/0014-4886(92). 1992. ↩︎