Arginase-1 catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle. In the brain, arginase activity influences nitric oxide production by competing with NOS for substrate. Dysregulation may affect neuroinflammation and excitotoxicity.
| Attribute | Value |
|---|---|
| Protein Name | Arginase-1 |
| Gene | ARG1 |
| UniProt ID | P05089 |
| PDB ID | 1HQ8 |
| Molecular Weight | 35 kDa |
| Subcellular Localization | Cytoplasm |
| Protein Family | Arginase family |
Arginase-1 is a Arginase family protein involved in various cellular processes in the nervous system.
Arginase-1 catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle. In the brain, arginase activity influences nitric oxide production by competing with NOS for substrate. Dysregulation may affect neuroinflammation and excitotoxicity.
Arginase deficiency leads to hyperargininemia. Altered arginase activity is observed in neurodegenerative conditions.
Arginase inhibitors are being investigated for various applications.