ARG1 catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle. In the brain, arginase activity influences nitric oxide production by competing with NOS for substrate. Dysregulation of arginase may affect neuroinflammation and excitotoxicity.
| Attribute | Value |
|---|---|
| Symbol | ARG1 |
| Full Name | Arginase 1 |
| Chromosome | 6q23.2 |
| NCBI Gene ID | 383 |
| OMIM ID | 608313 |
| UniProt ID | P05089 |
| Ensembl ID | ENSG00000118526 |
ARG1 catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle. In the brain, arginase activity influences nitric oxide production by competing with NOS for substrate. Dysregulation of arginase may affect neuroinflammation and excitotoxicity.