Apob Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| APOB — Apolipoprotein B | |
|---|---|
| Protein Name | Apolipoprotein B |
| Gene | [APOB](/proteins/apob-protein) |
| UniProt ID | P04114 |
| PDB Structure | 1L2B, 1EQG |
| Molecular Weight | 515 kDa (APOB-100), 240 kDa (APOB-48) |
| Subcellular Localization | Secreted, plasma VLDL/LDL |
| Protein Family | Apolipoprotein B family |
APOB (Apolipoprotein B) is a protein encoded by a gene located on chromosome 2p24.1. This protein is involved in various cellular processes including gene expression regulation, signal transduction, and metabolic functions. APOB plays important roles in neuronal function and is implicated in neurodegenerative diseases.
APOB is one of the largest proteins in nature and serves as the structural protein of VLDL and LDL particles.
APOB is essential for lipid transport:
Sniderman AD, et al. (2014). "Apolipoprotein B vs LDL-C as markers." JAMA. PMID:25196643
Rader DJ, Hovingh GK. (2014). "Lipoprotein(a) and cardiovascular disease." Lancet. PMID:25253126
Koudinov A, et al. (1996). "Apolipoprotein B in Alzheimer's disease brain." Lancet. PMID:8709718
Yao X, et al. (2022). "APOB and Alzheimer's disease." J Alzheimer's Dis. PMID:35180145
The study of Apob Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.