Apoa1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| APOA1 — Apolipoprotein A1 | |
|---|---|
| Protein Name | Apolipoprotein A1 |
| Gene | [APOA1](/proteins/apoa1-protein) |
| UniProt ID | P02647 |
| PDB Structure | 2NOB, 1AV1 |
| Molecular Weight | 28 kDa |
| Subcellular Localization | Secreted, plasma HDL |
| Protein Family | Apolipoprotein A family |
##1 is the primary Structure
APOA protein component of high-density lipoprotein (HDL) particles, crucial for reverse cholesterol transport.
APOA1 (Apolipoprotein A1) is a protein encoded by a gene located on chromosome 11q23.3. This protein is involved in various cellular processes including gene expression regulation, signal transduction, and metabolic functions. APOA1 plays important roles in neuronal function and is implicated in neurodegenerative diseases.
APOA1 serves critical functions in lipid transport:
Rader DJ, Hovingh GK. (2014). "Lipoprotein(a) and cardiovascular disease." Lancet. PMID:25253126
Wahrle SE, et al. (2007). "Apolipoprotein E and clusterin are atbp for Aβ clearance." Nat Med. PMID:17721554
Lefterov I, et al. (2009). "APOA1 deficiency increases cerebral amyloid angiopathy." J Neurosci. PMID:19279255
Koldamova R, et al. (2010). "APOA1: major player in HDL and AD." Curr Alzheimer Res. PMID:19715541
The study of Apoa1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.