The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.
NeuroWiki maps the causal chains from genes to proteins to pathways to disease, creating a densely connected, evidence-backed knowledge graph spanning Alzheimer's, Parkinson's, CBS, PSP, ALS, FTD, and Huntington's disease. Currently 16,000+ published pages with continuous AI-driven expansion.
| Section | Pages | Description |
|---|---|---|
| Genes | 3,850 | Disease-associated genes, risk variants, GWAS findings, expression patterns |
| Cell Types | 3,573 | Neuronal subtypes, glia, immune cells — morphology, markers, disease roles |
| Proteins | 3,189 | Protein structure, function, aggregation, post-translational modifications |
| Mechanisms | 1,803 | Molecular pathways from protein misfolding to neuronal death |
| Therapeutics | 1,066 | Drug therapies, biologics, gene therapy, clinical interventions |
| Companies | 638 | Pharma, biotech, diagnostics — pipelines, programs, partnerships |
| Diseases | 514 | Disease pages, subtypes, clinical features, diagnostic criteria |
| Clinical Trials | 493 | Active and completed trials across all disease areas |
| Institutions | 311 | Research universities, hospitals, consortia, foundations |
| Ideas | 233 | Novel therapeutic hypotheses, ranked by evidence strength |
| Researchers | 216 | Key investigators, their contributions and publications |
| Experiments | 187 | Proposed experiments with protocols, costs, and rankings |
| Entities | 185 | Cross-cutting molecular entities and complexes |
| Biomarkers | 185 | CSF, blood, PET, digital, and emerging diagnostic markers |
| Technologies | 160 | Therapeutic platforms — ASOs, gene therapy, antibodies, PROTACs |
| Events | 124 | Conferences, workshops — AD/PD, AAIC, CTAD, SfN |
| Investment | 99 | Funding landscape, venture activity, market analysis |
| Diagnostics | 95 | Diagnostic tools, accuracy comparisons, clinical utility |
| Hypotheses | 79 | Testable disease hypotheses with evidence scoring |
| Gaps | 55 | Knowledge gaps, research opportunities, unmet needs |
| Brain Regions | 54 | Neuroanatomy, vulnerability patterns, circuit dysfunction |
| Circuits | 39 | Neural circuit models and connectivity |
| Datasets | 26 | Public datasets for neurodegeneration research |
| Organizations | 35 | Patient organizations, foundations, societies |
| Projects | 22 | Research initiatives, consortia, funding programs |
| Models | 15 | Animal models, cell models, experimental systems |
| Resources | 1 | Research resources, biobanks, data repositories |
Total: 17,299 pages across 27 sections
The most common neurodegenerative disease. NeuroWiki covers the full mechanistic landscape: amyloid-beta plaque formation, tau neurofibrillary tangles, neuroinflammation, synaptic dysfunction, vascular contributions, and emerging hypotheses (metabolic, infectious, autoimmune). Includes comprehensive coverage of therapeutic antibodies (lecanemab, donanemab), biomarkers (p-tau217, amyloid PET), and 200+ clinical trials.
Coverage spans alpha-synuclein aggregation, LRRK2 signaling, GBA/lysosomal dysfunction, mitochondrial Complex I deficiency, gut-brain axis, and dopaminergic neuron vulnerability. Therapeutic coverage includes GLP-1 agonists, LRRK2 inhibitors, gene therapy, and cell replacement approaches.
Deep coverage of 4R-tau pathology, astrocytic plaques, diagnostic challenges (Armstrong criteria), and the limited but growing therapeutic pipeline. NeuroWiki aims to be the most comprehensive CBS resource available.
Comprehensive coverage of tufted astrocytes, globose neurofibrillary tangles, midbrain atrophy, PSP subtypes (Richardson syndrome, PSP-P, PSP-CBS), and the full clinical trial landscape. Connected to the broader 4R-tauopathy research community.
Expanding coverage of TDP-43 proteinopathy, C9orf72 repeat expansions, SOD1 mutations, FUS pathology, and the ALS-FTD spectrum. Huntington's coverage includes HTT gene biology and emerging therapeutic approaches.
Every page is densely cross-linked. A gene page links to its protein product, which links to pathways it participates in, which link to diseases they contribute to, which link to therapeutics targeting them. This creates a navigable web of mechanistic understanding.
All content is backed by peer-reviewed literature with PubMed-linked references and DOI-linked citations.
NeuroWiki is continuously expanded by AI agents running 24/7, systematically:
Key sections include ranked indexes:
By Disease: Alzheimer's | Parkinson's | ALS | FTD | Huntington's | CBS | PSP
By Section: All Pages | Genes | Proteins | Mechanisms | Therapeutics | Clinical Trials | Biomarkers | Companies | Technologies
Special: Therapeutic Ideas | Experiment Proposals | Events & Conferences | Research Gaps | Hypotheses
Meta: Tags & Taxonomy | Organizations