This index provides a comprehensive catalog of datasets relevant to neurodegenerative disease research, covering genomics, transcriptomics, proteomics, neuroimaging, and clinical data from major international consortia and research institutions. These datasets are essential resources for understanding disease mechanisms, identifying therapeutic targets, and developing biomarkers for Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease, frontotemporal dementia, and other neurodegenerative conditions.
Neurodegenerative diseases affect millions of people worldwide, and understanding their underlying biology requires large-scale, high-quality datasets. The research community has generated numerous public datasets spanning multiple modalities including genomic datasets, transcriptomic datasets, proteomic datasets, neuroimaging datasets, clinical datasets, and neuropathology datasets[1].
The past decade has seen an unprecedented expansion in the availability of large-scale biomedical datasets, driven by decreasing sequencing costs, increased neuroimaging capacity, and coordinated international efforts to share data. This democratization of data has transformed neurodegenerative disease research, enabling unprecedented insights into disease mechanisms and accelerating therapeutic development[2].
Total: 26 pages
| Dataset | Focus Area | Institution | Participants | Data Types |
|---|---|---|---|---|
| ADNI | Alzheimer's disease neuroimaging | University of California | 1,000+ | MRI, PET, CSF, genetic |
| PPMI | Parkinson's disease biomarkers | Michael J. Fox Foundation | 1,000+ | Clinical, imaging, biospecimens |
| AMP-AD | Alzheimer's disease proteomics | Multiple | 2,000+ | RNA-seq, proteomics |
| Allen Brain Atlas | Brain transcriptomics | Allen Institute | N/A | Transcriptomic |
| UK Biobank | Population genetics | Wellcome Trust | 500,000 | Genetic, imaging, clinical |
| PDBP | Parkinson's disease progression | National Institutes of Health | 2,000+ | Clinical, imaging |
| Project MinE | ALS genetics | Multiple | 15,000 planned | Whole genome sequencing |
| DIAN | Familial Alzheimer's | Washington University | 500+ | Longitudinal biomarker |
Most datasets require registration and acceptance of data use agreements. Key access portals include:
Beach et al. The importance of detailed enrollment in epidemiologic studies of neurodegenerative disease (2021). 2021. ↩︎
Weiner et al. The Alzheimer's Disease Neuroimaging Initiative (2012). 2012. ↩︎