This page ranks datasets for neurodegenerative disease research based on quality, accessibility, and scientific impact.
| Rank | Dataset | Impact Score | Citations | Quality |
|------|---------|--------------|-----------|---------|
| 1 | ADNI | 100 | 10,000+ | Very High |
| 2 | AMP-AD | 95 | 5,000+ | Very High |
| 3 | ROS/MAP | 90 | 3,000+ | High |
| 4 | Religious Orders | 85 | 2,500+ | High |
| 5 | Mayo Clinic | 80 | 2,000+ | High |
| Rank |
Dataset |
Access Score |
Ease of Use |
| 1 |
ADNI |
95 |
High |
| 2 |
GWAS Catalog |
90 |
Very High |
| 3 |
AMP-AD |
70 |
Moderate |
| 4 |
ROS/MAP |
65 |
Moderate |
| 5 |
Banner |
60 |
Moderate |
| Rank |
Dataset |
Impact Score |
Citations |
Quality |
| 1 |
PPMI |
100 |
5,000+ |
Very High |
| 2 |
AMP-PD |
90 |
1,500+ |
Very High |
| 3 |
MJFF |
80 |
1,000+ |
High |
| 4 |
PD Genetics |
85 |
2,000+ |
High |
| 5 |
NABEC |
70 |
500+ |
Moderate |
| Rank |
Dataset |
Sample Size |
Data Types |
| 1 |
PD Genetics |
50,000+ |
Genetic |
| 2 |
AMP-PD |
10,000+ |
Multi-omics |
| 3 |
PPMI |
2,000+ |
Clinical, imaging |
| 4 |
PD Brain Bank |
1,000+ |
Tissue |
| Rank |
Dataset |
Impact Score |
Citations |
Quality |
| 1 |
PRO-ACT |
95 |
2,000+ |
Very High |
| 2 |
Target ALS |
90 |
1,000+ |
Very High |
| 3 |
Project MinE |
85 |
1,500+ |
Very High |
| 4 |
NEALS |
80 |
800+ |
High |
| 5 |
ALS.net |
75 |
500+ |
High |
| Rank |
Dataset |
Data Types |
Integration |
| 1 |
Target ALS |
Clinical, omics, tissue |
Excellent |
| 2 |
PRO-ACT |
Clinical |
Good |
| 3 |
Project MinE |
Genomics |
Good |
| 4 |
ALSGene |
Genetic |
Excellent |
| Rank |
Dataset |
Disease |
Combined Score |
| 1 |
ADNI |
AD |
98 |
| 2 |
PPMI |
PD |
95 |
| 3 |
AMP-AD |
AD |
90 |
| 4 |
AMP-PD |
PD |
88 |
| 5 |
PRO-ACT |
ALS |
85 |
| Rank |
Dataset |
Disease |
Potential |
| 1 |
DIAN |
AD |
Very High |
| 2 |
A4 Study |
AD |
High |
| 3 |
SEPARATOR |
PD |
High |
| 4 |
CNS Consortium |
ALS |
Moderate |
| Factor |
Weight |
Measurement |
| Sample size |
25% |
Number of subjects |
| Data completeness |
25% |
Missing data % |
| Longitudinal |
20% |
Visit frequency |
| Multi-modal |
20% |
Data types |
| Curation |
10% |
QC standards |
The following neurodegenerative disease categories lack comprehensive dataset coverage:
- FTD (Frontotemporal Dementia) - No dedicated FTD dataset rankings
- Huntington's Disease - Limited dataset representation
- MSA (Multiple System Atrophy) - No dedicated section
- PSP (Progressive Supranuclear Palsy) - Missing
- CBS (Corticobasal Syndrome) - Missing
- ALS/FTD Overlap - Datasets covering both conditions
Important datasets not currently listed:
- DIAN - Dominantly Inherited Alzheimer's Network (already mentioned as underutilized)
- A4 Study - Anti-Amyloid Treatment in Asymptomatic AD
- TOPMed - NHLBI Trans-Omics for Precision Medicine
- Gnemega - Genetic resource for neurological disorders
- iPSC Consortium - Induced pluripotent stem cell datasets
- Cross-dataset integration scores missing
- No unified data access API or integration roadmap
- Missing multi-ethnic representation data
- Lack of pediatric/neurodevelopmental datasets
- Proteomics datasets - Limited coverage
- Metabolomics data - Missing from most rankings
- Single-cell datasets - Critical for cellular understanding
- Digital biomarker data - Emerging sensor data
- Real-world evidence - Clinical practice data
- Add FTD dataset rankings section
- Create Huntington's disease dataset page
- Add single-cell omics datasets
- Create dataset integration guide
- Add proteomics and metabolomics to data types