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| Symbol | STIM2 |
| Full Name | Stromal Interaction Molecule 2 |
| Chromosome | 4p16.3 |
| NCBI Gene | 57679 |
| OMIM | 605855 |
| Ensembl | ENSG00000120156 |
| UniProt | Q9UQC2 |
| Associated Diseases | Cognitive function, immunity |
STIM2 is a gene encoding a calcium sensor protein that regulates store-operated calcium entry and has been implicated in neurodegenerative diseases.
The STIM2 gene encodes an endoplasmic reticulum calcium sensor that activates plasma membrane calcium channels upon calcium store depletion. This process is critical for cellular calcium homeostasis.
Store-operated calcium entry is essential for maintaining cellular calcium levels and signaling. The STIM2 protein plays a key role in this process and has been implicated in calcium dysregulation observed in neurodegenerative diseases.
STIM2 is a calcium sensor similar to STIM1 but with lower affinity for calcium. It is important for basal calcium homeostasis and is implicated in neurodegeneration.
STIM2 is a calcium sensor that regulates SOCE. Important for neuronal function and immune response.
Expressed in brain and immune cells.