.infobox .infobox-gene {
background-color: #f8f9fa;
border: 1px solid #ddd;
padding: 10px;
width: 300px;
font-size: 0.9em;
}
.infobox .infobox-gene .gene-symbol {
font-weight: bold;
font-size: 1.2em;
color: #2c5282;
}
.infobox .infobox-gene .gene-name {
font-style: italic;
margin-bottom: 10px;
}
.infobox .infobox-gene table {
width: 100%;
border-collapse: collapse;
}
.infobox .infobox-gene td {
padding: 4px;
vertical-align: top;
}
.infobox .infobox-gene td.label {
font-weight: bold;
width: 40%;
color: #555;
}
.infobox .infobox-gene td.value {
width: 60%;
}
.infobox .infobox-gene a {
color: #0066cc;
text-decoration: none;
}
.infobox .infobox-gene a:hover {
text-decoration: underline;
}
| Symbol | ORAI1 |
| Full Name | Calcium Release-Activated Calcium Channel Protein 1 |
| Chromosome | 12q24.31 |
| NCBI Gene | 84876 |
| OMIM | 610277 |
| Ensembl | ENSG00000182578 |
| UniProt | Q8WTG4 |
| Associated Diseases | Immunodeficiency |
ORAI1 is a gene encoding a calcium release-activated calcium (CRAC) channel that mediates store-operated calcium entry and has been implicated in neurodegenerative diseases.
The ORAI1 gene encodes the pore subunit of CRAC channels, which are the primary pathway for calcium influx in response to ER calcium depletion.
CRAC channels are critical for calcium signaling in immune cells and neurons. The ORAI1 channel has been studied in the context of neuroinflammation and neurodegeneration.
ORAI1 is the pore subunit of the calcium release-activated calcium (CRAC) channel. It is essential for store-operated calcium entry and immune cell function.
ORAI1 is the pore subunit of store-operated calcium channels. Critical for calcium influx and immune function.
Expressed in immune cells and various tissues.