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| Symbol | STIM1 |
| Full Name | Stromal Interaction Molecule 1 |
| Chromosome | 11p15.5 |
| NCBI Gene | 6787 |
| OMIM | 605854 |
| Ensembl | ENSG00000167323 |
| UniProt | Q13586 |
| Associated Diseases | Immunodeficiency, myopathy |
STIM1 is a gene encoding a calcium sensor protein that regulates store-operated calcium entry and has been implicated in neurodegenerative diseases.
The STIM1 gene encodes an endoplasmic reticulum calcium sensor that activates plasma membrane calcium channels upon calcium store depletion. This process is critical for cellular calcium homeostasis.
Store-operated calcium entry is essential for maintaining cellular calcium levels and signaling. The STIM1 protein plays a key role in this process and has been implicated in calcium dysregulation observed in neurodegenerative diseases.
STIM1 is a calcium sensor in the endoplasmic reticulum that activates store-operated calcium entry channels (ORAI and TRPC channels) when calcium stores are depleted.
STIM1 is a calcium sensor that activates store-operated calcium entry (SOCE). Critical for immune cell function and muscle.
Widely expressed.