| POLE — DNA Polymerase Epsilon | |
|---|---|
| Symbol | POLE |
| Full Name | DNA Polymerase Epsilon |
| Chromosome | 12q24.3 |
| NCBI Gene | 5426 |
| Ensembl | ENSG00000177042 |
| OMIM | 174762 |
| UniProt | Q07864 |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Colorectal Cancer, FILS Syndrome |
| Expression | Hippocampus, Cerebral cortex, Cerebellum, Substantia nigra |
| Key Mutations | |
Pole — Dna Polymerase Epsilon is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
POLE (DNA Polymerase Epsilon) is a gene located on chromosome 12q24.3 that plays a critical role in neurodegenerative disease. Mutations in POLE are associated with Alzheimer's Disease, Parkinson's Disease, Colorectal Cancer, FILS Syndrome. The gene is catalogued as NCBI Gene ID 5426 and OMIM 174762.
The POLE gene encodes a protein that is expressed in multiple brain regions including Hippocampus, Cerebral cortex, Cerebellum, Substantia nigra. The normal function of this gene product is essential for neuronal health and survival.
Expression data is available from the Allen Human Brain Atlas.
POLE mutations are linked to the following neurodegenerative conditions:
Publication list pending enrichment from PubMed.
The study of Pole — Dna Polymerase Epsilon has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki gene database. Last updated: 2026-02-26.