Lgi2 — Leucine Rich Glioma Inactivated 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Leucine-Rich Glioma Inactivated 2 | |
|---|---|
| Gene Symbol | LGI2 |
| Full Name | leucine-rich glioma inactivated 2 |
| Chromosome | 4p15.2 |
| NCBI Gene ID | 54597 |
| OMIM | 607301 |
| Ensembl ID | ENSG00000153902 |
| UniProt ID | Q8N0W4 |
| Associated Diseases | |
| Autosomal Dominant Lateral Temporal Epilepsy (modifier), Alzheimer's Disease | |
The LGI2 gene encodes a protein homologous to LGI1.
LGI2 is a member of the LGI (Leucine-Rich, Glioma Inactivated) family of secreted proteins. Like LGI1, LGI2 interacts with ADAM22 and ADAM23 receptors.
Key functions include:
LGI2 is expressed in:
LGI2 is a family member of LGI1 with overlapping but distinct functions.
The study of Lgi2 — Leucine Rich Glioma Inactivated 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.