Lgi1 — Leucine Rich Glioma Inactivated 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Leucine-Rich Glioma Inactivated 1 | |
|---|---|
| Gene Symbol | LGI1 |
| Full Name | leucine-rich glioma inactivated 1 |
| Chromosome | 10q24.3 |
| NCBI Gene ID | 2709 |
| OMIM | 604619 |
| Ensembl ID | ENSG00000162711 |
| UniProt ID | O75771 |
| Associated Diseases | Autosomal Dominant Lateral Temporal Epilepsy, Alzheimer's Disease |
The LGI1 (Leucine-Rich Glioma Inactivated 1) gene encodes a leucine-rich repeat protein that plays important roles in synaptic function and neuronal development.
LGI1 (Leucine-Rich Glioma Inactivated 1) is a neuronal secreted protein that plays critical roles in synaptic transmission and neuronal excitability. Originally identified as a tumor suppressor gene in gliomas, LGI1 has emerged as a crucial regulator of synaptic function.
Key functions include:
LGI1 is highly expressed in the brain:
Expression is predominantly neuronal, with highest levels in synaptic fractions.
LGI1 is a critical synaptic protein linking neuronal excitability to neurodegenerative processes.
The study of Lgi1 — Leucine Rich Glioma Inactivated 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.