Apbb1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Amyloid Precursor Protein Binding Family B Member 1 | |
|---|---|
| Gene Symbol | APBB1 |
| Full Name | amyloid beta precursor protein binding family B member 1 |
| Chromosome | 11p15.4 |
| NCBI Gene ID | 326 |
| OMIM | 602294 |
| Ensembl ID | ENSG00000196913 |
| UniProt ID | Q9UKP3 |
| Associated Diseases | Alzheimer's Disease, Frontotemporal Dementia |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
APBB1 (Amyloid Precursor Protein Binding Family B Member 1), also known as Fe65, is a neuronal adaptor protein that plays critical roles in APP (Amyloid Precursor Protein) processing and signaling. APBB1 contains several functional domains including:
Key functions include:
APBB1 is highly expressed in the brain, particularly in:
Expression is neuron-specific and enriched in synaptic compartments.
APBB1 is a critical hub protein linking APP processing to downstream signaling pathways in neurodegeneration.
The study of Apbb1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.