Mapt — Microtubule Associated Protein Tau plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Mapt — Microtubule Associated Protein Tau is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value |
|---|---|
| Gene Symbol | MAPT |
| Full Name | Microtubule-Associated Protein Tau |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 4137 |
| OMIM ID | 157140 |
| Ensembl ID | ENSG00000186868 |
| UniProt ID | P10636 |
| Encoded Protein | Tau protein |
| Associated Diseases | Alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration |
MAPT encodes the microtubule-associated protein tau (tau), a neuronal microtubule-stabilizing protein that plays critical roles in axonal transport, neuronal polarity, and synaptic function. In Alzheimer's disease and related tauopathies, tau becomes hyperphosphorylated, aggregates into neurofibrillary tangles, and loses its normal functions.
Key normal physiological functions include:
The MAPT gene produces six tau isoforms through alternative splicing (0N, 1N, 2N; 3R, 4R).
Tau pathology correlates strongly with cognitive decline in AD:
Over 50 MAPT mutations cause autosomal dominant FTDP-17:
The H1 haplotype of MAPT is the major genetic risk factor:
Also associated with MAPT H1 haplotype:
Tau is predominantly expressed in neurons:
The Allen Brain Atlas shows high MAPT expression in:
Mapt — Microtubule Associated Protein Tau plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Mapt — Microtubule Associated Protein Tau has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.