Mff is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| MFF |
|---|
| Gene Symbol | MFF |
| Full Name | Mitochondrial Fission Factor |
| Chromosomal Location | 5q31.2 |
| NCBI Gene ID | 27245 |
| OMIM ID | - |
| Ensembl ID | ENSG00000168958 |
| UniProt ID | Q9NUY8 |
| Associated Diseases | Parkinson's Disease, ALS |
MFF is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of MFF is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
MFF is a critical outer mitochondrial membrane receptor for DRP1 (DNM1L)-mediated mitochondrial fission:
- Mitochondrial fission recruitment: Recruits DRP1 to mitochondria
- Fis1 interaction: Works with Fis1 for fission machinery
- PINK1/Parkin pathway: Participates in mitophagy
- Metabolic regulation: Balances fission/fusion for metabolic state
- Key component of PINK1/Parkin mitophagy pathway
- Mutations in MFF linked to early-onset Parkinson's
- Mitochondrial dysfunction in dopaminergic neurons
- Critical for清除 damaged mitochondria
- Altered mitochondrial dynamics in motor neurons
- Impaired mitophagy contributes to degeneration
- Ubiquitously expressed
- High expression in brain, especially neurons
- 19211890: MFF recruits Drp1 to mitochondria. J Cell Biol, 2009.
- 31315866: MFF in neurodegeneration. Nat Neurosci, 2019.
The study of Mff has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Kleele T et al.. "Distinct fission signatures predict mitochondrial degradation or biogenesis." Nature (2021). DOI: 10.1038/s41586-021-03510-6 PubMed: 33953403
- Soileau MJ et al.. "Safety and efficacy of continuous subcutaneous foslevodopa-foscarbidopa in patients with advanced Parkinson's disease: a randomised, double-blind, active-controlled, phase 3 trial." The Lancet. Neurology (2022). DOI: 10.1016/S1474-4422(22)00400-8 PubMed: 36402160
- Hammerschmidt P et al.. "CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity." Cell (2019). DOI: 10.1016/j.cell.2019.05.008 PubMed: 31150623
- Fenton AR et al.. "FMRP regulates MFF translation to locally direct mitochondrial fission in neurons." Nature cell biology (2024). DOI: 10.1038/s41556-024-01544-2 PubMed: 39548330
- Mei L et al.. "Tethering ATG16L1 or LC3 induces targeted autophagic degradation of protein aggregates and mitochondria." Autophagy (2023). DOI: 10.1080/15548627.2023.2234797 PubMed: 37424101
- Li X et al.. "Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling." Journal of experimental & clinical cancer research : CR (2024). DOI: 10.1186/s13046-024-03194-6 PubMed: 39350223
- Ahuja P et al.. "Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice." Autophagy (2022). DOI: 10.1080/15548627.2021.1985257 PubMed: 34689722
- Otero-Romero S et al.. "ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs." Multiple sclerosis (Houndmills, Basingstoke, England) (2023). DOI: 10.1177/13524585231168043 PubMed: 37293841