Mff Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| MFF Protein |
|---|
| Protein Name | Mitochondrial Fission Factor |
| Gene | MFF |
| UniProt ID | Q9NUY8 |
| PDB IDs | 5ARH |
| Molecular Weight | 34 kDa |
| Subcellular Localization | Outer mitochondrial membrane |
| Protein Family | Mitochondrial fission factors |
MFF PROTEIN is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of MFF PROTEIN is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
MFF is a small mitochondrial outer membrane protein:
- N-terminal transmembrane domain: Anchors to outer membrane
- Cytosolic domain: Interacts with DRP1
- Tetrameric structure: Forms receptor complexes
- DRP1 recruitment: Primary receptor for DRP1 on mitochondria
- Fission coordination: Initiates mitochondrial fission
- Fis1 interaction: Works with Fis1 for complete fission
- Mitophagy receptor: Participates in PINK1/Parkin mitophagy
- Metabolic adaptation: Adjusts mitochondrial network for metabolic state
- Essential for mitophagy
- Mutations cause early-onset PD
- PINK1/Parkin pathway dysfunction
- Altered mitochondrial dynamics
- Impaired mitophagy in motor neurons
- 19211890: MFF recruits Drp1. J Cell Biol, 2009.
- 31315866: MFF in neurodegeneration. Nat Neurosci, 2019.
The study of Mff Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Kleele T et al.. "Distinct fission signatures predict mitochondrial degradation or biogenesis." Nature (2021). DOI: 10.1038/s41586-021-03510-6 PubMed: 33953403
- Soileau MJ et al.. "Safety and efficacy of continuous subcutaneous foslevodopa-foscarbidopa in patients with advanced Parkinson's disease: a randomised, double-blind, active-controlled, phase 3 trial." The Lancet. Neurology (2022). DOI: 10.1016/S1474-4422(22)00400-8 PubMed: 36402160
- Hammerschmidt P et al.. "CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity." Cell (2019). DOI: 10.1016/j.cell.2019.05.008 PubMed: 31150623
- Fenton AR et al.. "FMRP regulates MFF translation to locally direct mitochondrial fission in neurons." Nature cell biology (2024). DOI: 10.1038/s41556-024-01544-2 PubMed: 39548330
- Mei L et al.. "Tethering ATG16L1 or LC3 induces targeted autophagic degradation of protein aggregates and mitochondria." Autophagy (2023). DOI: 10.1080/15548627.2023.2234797 PubMed: 37424101
- Li X et al.. "Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling." Journal of experimental & clinical cancer research : CR (2024). DOI: 10.1186/s13046-024-03194-6 PubMed: 39350223
- Ahuja P et al.. "Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice." Autophagy (2022). DOI: 10.1080/15548627.2021.1985257 PubMed: 34689722
- Otero-Romero S et al.. "ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs." Multiple sclerosis (Houndmills, Basingstoke, England) (2023). DOI: 10.1177/13524585231168043 PubMed: 37293841