Dnm1L Gene (Drp1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
DNM1L DNM1L (Dynamin 1-like protein/DRP1) mediates mitochondrial fission. Critical for mitochondrial dynamics in neurons. Mutations cause developmental disorders.
Chromosomal location: 12p24.11
DNM1L mutations or dysregulation contribute to neurodegenerative diseases through various mechanisms.
Modulating DNM1L expression or function may have therapeutic potential for neurodegenerative disease treatment.
Symbol: DNM1L
Full Name: Dynamin 1-Like Protein (DRP1)
Chromosomal Location: 12p11.21
NCBI Gene ID: 10098
Ensembl ID: ENSG00000087448
UniProt ID: O00429
OMIM: 603850
Dynamin 1-like protein (DRP1), encoded by DNM1L, is a GTPase essential for mitochondrial fission. It translocates from cytosol to mitochondria to mediate membrane scission during division[1].
DRP1 orchestrates mitochondrial division:
DRP1 also divides peroxisomes:
DRP1 activity is tightly regulated:
DRP1 alterations in AD:
In PD, DRP1 is implicated:
DRP1 mutations cause spastic paraplegia:
DRP1 mutations cause severe phenotypes:
DRM1 is ubiquitously expressed with high levels in:
In neurons, DRP1 localizes to synapses and regulates mitochondrial distribution for energy demands.
Targeting excessive fission:
Targeting regulatory kinases:
Smirnova E, et al. (2001). "Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells." J Cell Biol. 159(6):931-938. [DOI:10.1083/jcb.200110046^1]
Gawlowski T, et al. (2012). "Modulation of DRP1 phosphorylation by O-GlcNAcylation." Pflugers Arch. 464(1):1-12. [DOI:10.1007/s00424-012-1107-7^2]
Wang X, et al. (2008). "Dynamin-like protein 1 reduction underlies mitochondrial fragmentation and oxidative stress in adult Alzheimer's disease." J Neurosci. 28(44):11111-11122. [DOI:10.1523/JNEUROSCI.2519-08.2008^3]
Liu Y, et al. (2021). "Inhibition of Drp1 provides neuroprotection in Parkinson's disease models." Neurobiol Dis. 158:105472. [DOI:10.1016/j.nbd.2021.105472^4]
The study of Dnm1L Gene (Drp1) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Smirnova E, et al. (2001). "Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells." J Cell Biol. 159(6):931-938. DOI:10.1083/jcb.200110046 ↩︎
Gawlowski T, et al. (2012). "Modulation of DRP1 phosphorylation by O-GlcNAcylation." Pflugers Arch. 464(1):1-12. DOI:10.1007/s00424-012-1107-7 ↩︎
Wang X, et al. (2008). "Dynamin-like protein 1 reduction underlies mitochondrial fragmentation and oxidative stress in adult Alzheimer's disease." J Neurosci. 28(44):11111-11122. DOI:10.1523/JNEUROSCI.2519-08.2008 ↩︎
Liu Y, et al. (2021). "Inhibition of Drp1 provides neuroprotection in Parkinson's disease models." Neurobiol Dis. 158:105472. DOI:10.1016/j.nbd.2021.105472 ↩︎