Bcl2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
title: BCL2 Gene ---
| Full Name | B-Cell Leukemia/Lymphoma 2 |
|---|---|
| Chromosomal Location | 18q21.33 |
| NCBI Gene ID | 596 |
| OMIM | 151430 |
| Ensembl ID | ENSG00000171791 |
| UniProt | P10415 |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease, Multiple Sclerosis, Stroke |
The BCL2 gene encodes B-Cell Leukemia/Lymphoma 2 (BCL-2), an anti-apoptotic protein central to cell survival:
BCL-2 is an integral mitochondrial outer membrane protein. It contains BCL-2 homology (BH) domains BH1, BH2, BH3, and BH4. Its anti-apoptotic function is mediated by sequestering pro-apoptotic proteins and directly inhibiting BAX/BAK pore formation.
Vaux DL, et al. (1988). "Bcl-2 and the regulation of programmed cell death." J Cell Biol. PMID:3133420
Offen D, et al. (2009). "BCL-2 and Parkinson's disease." J Neural Transm. PMID:18506381
Congo Y, et al. (2022). "BCL-2 as a therapeutic target in Alzheimer's disease." Nat Rev Neurol. PMID:35680911
Martin LJ, et al. (2020). "The BCL-2 family in the nervous system." Nat Rev Neurosci. PMID:32661312
The study of Bcl2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Vaux DL, et al. (1988). Bcl-2 and the regulation of programmed cell death. J Cell Biol. PMID:3133420.
Offen D, et al. (2009). BCL-2 and Parkinson's disease. J Neural Transm. PMID:18506381.
Congo Y, et al. (2022). BCL-2 as a therapeutic target in Alzheimer's disease. Nat Rev Neurol. PMID:35680911.
Martin LJ, et al. (2020). The BCL-2 family in the nervous system. Nat Rev Neurosci. PMID:32661312.