Bak1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
title: BAK1 Gene ---
| Full Name | BCL2-Antagonist/Killer 1 |
|---|---|
| Chromosomal Location | 6p21.31 |
| NCBI Gene ID | 578 |
| OMIM | 602516 |
| Ensembl ID | ENSG00000030110 |
| UniProt | Q9Y2D6 |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease, Stroke |
The BAK1 gene encodes BCL2-Antagonist/Killer 1 (BAK1), a pro-apoptotic member of the BCL-2 family:
BAK1 is a tail-anchored protein integrated into the mitochondrial outer membrane. It contains BH1, BH2, and BH3 domains. Unlike BAX, it is constitutively mitochondrial.
Korsmeyer SJ, et al. (2000). "Pro-apoptotic cascade." Cell. PMID:10871281
Wei MC, et al. (2001). "BAK/BAX activation." Genes Dev. PMID:11358867
Wang X, et al. (2019). "BAK in neurodegeneration." Cell Death Differ. PMID:30590037
The study of Bak1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Korsmeyer SJ, et al. (2000). Pro-apoptotic cascade. Cell. PMID:10871281.
Wei MC, et al. (2001). BAK/BAX activation in apoptosis. Genes Dev. PMID:11358867.
Wang X, et al. (2019). BAK in neurodegeneration. Cell Death Differ. PMID:30590037.