Bax Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
title: BAX Gene ---
| Full Name | BCL2-Associated X Protein |
|---|---|
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 581 |
| OMIM | 600040 |
| Ensembl ID | ENSG00000087088 |
| UniProt | Q07812 |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Stroke |
The BAX gene encodes BCL2-Associated X Protein (BAX), a pro-apoptotic member of the BCL-2 family:
BAX is normally localized in the cytosol. Upon apoptotic stimuli, it translocates to mitochondria and undergoes conformational change, inserting into the outer membrane as a homo-oligomeric pore.
Oltvai ZN, et al. (1993). "Bcl-2 and Bax: a regulatory switch with a lethal function." Cell. PMID:8258054
Yuan J, et al. (2019). "Bax and Bak cooperate with but function downstream of caspase-8 in axonal degeneration." Neuron. PMID:31121478
D'Amelio M, et al. (2012). "Bax deficiency prevents neuron death in models of Alzheimer's disease." Cell Death Differ. PMID:22577063
Martin LJ, et al. (2020). "Bax and Bak in neurodegenerative diseases." Neurobiol Dis. PMID:32061626
The study of Bax Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Oltvai ZN, et al. (1993). Bcl-2 and Bax: a regulatory switch with a lethal function. Cell. PMID:8258054.
Yuan J, et al. (2019). Bax and Bak cooperate with but function downstream of caspase-8 in axonal degeneration. Neuron. PMID:31121478.
D'Amelio M, et al. (2012). Bax deficiency prevents neuron death in models of Alzheimer's disease. Cell Death Differ. PMID:22577063.
Martin LJ, et al. (2020). Bax and Bak in neurodegenerative diseases. Neurobiol Dis. PMID:32061626.