ZCWPW1 Protein is a protein encoded by the ZCWPW1 gene that zcwpw1 is a chromatin-associated protein with epigenetic regulatory functions:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
ZCWPW1 (Zinc finger CW-type and PWWP domain containing 1)
{| class="infobox-table"
! colspan="2" | ZCWPW1 Protein
|-
| Gene
| [ZCWPW1](/genes/zcwpw1)
|-
| UniProt
| [Q9P0M4](https://www.uniprot.org/uniprot/Q9P0M4)
|-
| Molecular Weight
| ~61 kDa
|-
| Subcellular Localization
| Nucleus
|-
| Protein Family
| CW-type zinc finger family
|-
| Aliases
| CCDC, CW-PWWP
|}
ZCWPW1 contains multiple functional domains:
- CW-type zinc finger domain: DNA-binding domain recognizing specific chromatin modifications
- PWWP domain: Methyl-lysine binding domain involved in chromatin reader function
- Coiled-coil region: Protein-protein interactions
ZCWPW1 is a chromatin-associated protein with epigenetic regulatory functions:
- Histone modification recognition: Binds to specific histone methylation marks
- Chromatin remodeling: Involved in epigenetic regulation of gene expression
- Transcriptional regulation: Modulates transcription through chromatin interactions
- Cell cycle regulation: Some evidence for role in cell proliferation
ZCWPW1 has been identified as a risk gene for late-onset Alzheimer's disease:
- Genetic association: GWAS-identified risk locus for late-onset AD
- Brain expression: Expressed in various brain regions including hippocampus
- Potential mechanisms:
- May affect epigenetic regulation of neuronal genes
- Could influence neuroinflammation through glial cell function
- May modify tau pathology through transcriptional regulation
- Pathology: Altered expression in AD brain tissue
- Frontotemporal dementia: Potential role in epigenetic dysregulation
- Parkinson's disease: Possible involvement in dopaminergic gene regulation