Epigenetic regulation refers to heritable and reversible control of gene expression without changing the underlying DNA sequence. Major mechanisms include DNA methylation, histone modification, chromatin remodeling, and regulatory non-coding RNAs.[1][2]
In neurodegenerative disease, epigenetic disruption can alter neuronal identity programs, stress responses, inflammatory tone, proteostasis, and vulnerability to toxic protein accumulation.[1:1][2:1] The pathway is therefore central to how environmental exposures, aging, and genetic background converge on disease expression.
Epigenetics in Neurodegenerative Diseases. Subcellular Biochemistry (2025). ↩︎ ↩︎
Epigenetics-Based Therapeutics for Neurodegenerative Disorders. Current Translational Geriatrics and Experimental Gerontology Reports (2012). ↩︎ ↩︎