YWHAB Protein is a protein that 14-3-3 proteins are involved in numerous cellular processes:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta), also known as 14-3-3 beta, is a member of the 14-3-3 family of adapter proteins that regulate signal transduction, cell cycle progression, and apoptosis.
| Property | Value |
|---|---|
| Gene | YWHAB |
| UniProt ID | P31946 |
| PDB Structure | 1BJ1, 2BQ0, 4FGU |
| Molecular Weight | 28 kDa |
| Subcellular Localization | Cytoplasm, nucleus |
| Protein Family | 14-3-3 family |
YWHAB forms homodimers and heterodimers with other 14-3-3 proteins. Each monomer consists of nine alpha-helices arranged in an antiparallel configuration, creating a amphipathic groove that binds phosphorylated serine/threonine motifs on target proteins[1].
14-3-3 proteins are involved in numerous cellular processes:
Strategies targeting 14-3-3 protein interactions:
Structure of 14-3-3 protein isoforms. Current Opinion in Structural Biology. 2002. ↩︎
14-3-3 proteins in Alzheimer's disease. Journal of Alzheimer's Disease. 2005. ↩︎
14-3-3 proteins in Parkinson's disease. Brain Research Reviews. 2008. ↩︎