The YWHAB gene (Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Beta) encodes the beta isoform of 14-3-3 proteins, one of the most abundant and widely expressed isoforms. The 14-3-3 proteins are a family of conserved adaptor molecules that regulate diverse cellular processes by binding to phosphorylated serine/threonine motifs on target proteins. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Gene Symbol | YWHAB | [4]
| Full Name | Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Beta | [5]
| Chromosomal Location | 20q13.13 |
| NCBI Gene ID | 7533 |
| Ensembl ID | ENSG00000153013 |
| UniProt ID | P62226 |
| OMIM | 601290 |
YWHAB encodes 14-3-3 beta, a ubiquitously expressed isoform with critical neuronal functions:
| Disease | Association Type | Mechanism |
|---|---|---|
| Alzheimer's Disease | Modifier/Biomarker | 14-3-3 beta interacts with tau; elevated CSF levels in AD patients |
| Parkinson's Disease | Potential Role | May modulate alpha-synuclein aggregation and neuronal survival |
| Amyotrophic Lateral Sclerosis | Modifier | Interacts with TDP-43, FUS in stress granules |
| Huntington's Disease | Modifier | May affect mutant huntingtin aggregation and toxicity |
YWHAB is expressed ubiquitously with high expression in:
Yau W, et al. 14-3-3 isoforms in neurodegenerative diseases. Journal of Neural Transmission. 2015. ↩︎
Kim H, et al. 14-3-3 beta prevents neuronal apoptosis. Cell Death Discovery. 2020. ↩︎
Satoh J, et al. Molecular network of 14-3-3 proteins in Alzheimer's disease. Acta Neuropathologica. 2007. ↩︎
Steinacker P, et al. Neuronal 14-3-3 proteins in health and disease. Journal of Neural Transmission. 2011. ↩︎
Benzinger A, et al. [Cerebrospinal fluid 14-3-3 proteins as biomarkers](https://doi.org/10.1016/S1474-4422(05). Lancet Neurology. 2005. ↩︎