Xrcc4 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | XRCC4 |
|---|---|
| Gene Symbol | [XRCC4](/genes/xrcc4) |
| UniProt ID | Q16374 |
| Molecular Weight | ~33 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | DNA repair protein |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
XRCC4 is a 336-amino acid protein with an elongated structure:
XRCC4 forms a stable heterodimer with XLF (Cernunnos/XRCC4-like factor) and a heterotetramer with DNA ligase IV.
XRCC4 is essential for classical non-homologous end joining (c-NHEJ), the predominant pathway for repairing DNA double-strand breaks:
NHEJ Complex Assembly:
Biological Functions:
Cancer:
Immunodeficiency:
Therapeutic targeting:
No direct XRCC4-targeted drugs in clinical use.
XRCC4 Gene, Non-Homologous End Joining, DNA Repairmechanisms/dna-repair-neurodegeneration), LIG4 Protein
The study of Xrcc4 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.