Dna Ligase Iv Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein Name | DNA Ligase IV |
|---|---|
| Gene Symbol | [LIG4](/genes/lig4) |
| UniProt ID | P18858 |
| Molecular Weight | ~100 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | DNA ligase family |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
DNA Ligase IV is a 911-amino acid protein with a unique architecture:
Forms a stable 1:1 complex with XRCC4 through the BRCT domain interactions.
DNA Ligase IV is the ligase specifically required for the final step of classical NHEJ:
Ligation Reaction:
Biological Functions:
In neurons, LIG4-mediated repair is important for maintaining genomic integrity despite the lack of replication.
LIG4 Syndrome:
Cancer:
Therapeutic approaches:
Clinical applications limited by the essential nature of NHEJ.
LIG4 Gene, Non-Homologous End Joining, XRCC4 Protein, DNA Repairmechanisms/dna-repair-neurodegeneration)
The study of Dna Ligase Iv Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.