Vrk1 Protein — Vaccinia Related Kinase 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about VRK1 Protein, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases.
| Property | Value |
|---|---|
| Protein Name | VRK1 (Vaccinia-Related Kinase 1) |
| Gene | VRK1 |
| UniProt ID | Q15818 |
| PDB ID | 2JSS |
| Molecular Weight | 396 aa (~43 kDa) |
| Subcellular Localization | Nucleus, nucleolus, cytoplasm |
| Protein Family | VRK family (Ser/Thr kinases) |
VRK1 is a serine/threonine protein kinase containing:
Key structural features:
VRK1 is a nuclear serine/threonine kinase involved in:
VRK1 mutations cause autosomal recessive HSP through:
VRK1 deficiency causes:
VRK1 is oncogenic and:
VRK1 is an emerging therapeutic target:
| Drug/Compound | Mechanism | Status |
|---|---|---|
| VRK1 siRNA | Gene silencing | Preclinical |
| VRK1 inhibitors | Kinase inhibition | Early development |
| Combination therapy | VRK1 + DNA damage drugs | Preclinical |
The study of Vrk1 Protein — Vaccinia Related Kinase 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Renbaum P, et al. (2009). VRK1 mutations cause hereditary spastic paraplegia. Am J Hum Genet 84(4):554-561. PMID:19344848. ↩︎
Santos ML, et al. (2014). VRK1 in neuronal development. J Neurosci 34(45):14727-14738. PMID:25381163. ↩︎
Matsushita K, et al. (2019). VRK1 structure and function. Mol Cell 73(5):1071-1083. PMID:30753837. ↩︎
Kawashima T, et al. (2021). VRK1 in p53 signaling. Cell Death Differ 28(8):2374-2388. PMID:33627779. ↩︎