The Vipr1 protein (Vasoactive Intestinal Peptide Receptor 1) is a Secretin receptor family (Class B GPCR) member involved in Receptor for vasoactive intestinal peptide (VIP), involved in neuroprotection, immune modulation, and circadian rhythm regulation. This page provides detailed information about its structure, function, and role in neurodegenerative diseases.
| Vipr1 (Vasoactive Intestinal Peptide Receptor 1) | |
|---|---|
| Official Symbol | Vipr1 |
| Gene | VIPR1 |
| Chromosomal Location | 3p22.1 |
| UniProt ID | P32246 |
| Molecular Weight | ~50 kDa |
| Subcellular Localization | Cell membrane (GPCR) |
| Protein Family | Secretin receptor family (Class B GPCR) |
Receptor for vasoactive intestinal peptide (VIP), involved in neuroprotection, immune modulation, and circadian rhythm regulation. This protein plays important roles in cellular signaling pathways relevant to neurodegenerative disease pathogenesis.
Vipr1 participates in key signaling cascades:
Receptor for vasoactive intestinal peptide (VIP), involved in neuroprotection, immune modulation, and circadian rhythm regulation. In the central nervous system, this protein:
Vipr1 is implicated in Alzheimer's disease through:
In Parkinson's disease:
Vipr1 plays a role in:
Vipr1 is being investigated as a therapeutic target:
Vipr1 interacts with:
The study of Vipr1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.