TUBG1 Protein is a protein that in neurons, gamma-tubulin plays critical roles in:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
TUBG1 (Tubulin Gamma 1) is a member of the tubulin family essential for microtubule organization in eukaryotic cells.
| Property | Value |
|---|---|
| Gene | TUBG1 |
| UniProt ID | P23258 |
| PDB Structure | 5IJ7, 6JO4 |
| Molecular Weight | 51 kDa |
| Subcellular Localization | Centrosome, spindle pole bodies |
| Protein Family | Tubulin family |
TUBG1 is a gamma-tubulin that forms the core of the gamma-tubulin ring complex (gamma-TuRC), which serves as a microtubule organizing center (MTOC) in cells. The gamma-tubulin complex consists of gamma-tubulin and several gamma-tubulin complex proteins (GCPs)[1].
In neurons, gamma-tubulin plays critical roles in:
Current therapeutic approaches targeting microtubule function in neurodegeneration include:
Crystal structure of the human gamma-tubulin complex. Nature. 2007. ↩︎
Microtubule dysfunction in Alzheimer's disease. Journal of Alzheimer's Disease. 2017. ↩︎
14-3-3 proteins as therapeutic targets in neurodegeneration. Journal of Parkinson's Disease. 2022. ↩︎
Alpha-synuclein and 14-3-3 protein interactions in Parkinson's disease. Journal of Molecular Neuroscience. 2020. ↩︎