Trpm2 Protein Transient Receptor Potential Melastatin 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TRPM2 (Transient Receptor Potential Melastatin 2) is a calcium-permeable nonselective cation channel that functions as a oxidative stress sensor. It is activated by adenosine diphosphate ribose (ADPR) and oxidative stress, and plays important roles in oxidative stress response, cell death, and various cellular signaling pathways. [1]
| Property | Value | [2]
|----------|-------| [3]
| Protein Name | Transient receptor potential cation channel subfamily M member 2 |
| Gene Symbol | TRPM2 |
| UniProt ID | Q9NZQ8 |
| Molecular Weight | ~203 kDa |
| Protein Length | 1705 amino acids |
| Chromosomal Location | 21q22.12 |
TRPM2 has a complex structure unique among TRP channels:
| Strategy | Agent | Status |
|---|---|---|
| TRPM2 Antagonists | ADC, M8KC | Preclinical |
| Calcium Channel Blockers | Various | Approved |
| Antioxidants | N-acetylcysteine | Approved |
| Gene Silencing | siRNA | Experimental |
The study of Trpm2 Protein Transient Receptor Potential Melastatin 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.