| TRPC1 — Transient Receptor Potential Canonical 1 | |
|---|---|
| Protein Name | TRPC1 |
| Gene | [TRPC1](/genes/trpc1) |
| UniProt ID | P48995 |
| Molecular Weight | ~90 kDa (793 amino acids) |
| Subcellular Localization | Plasma membrane, Endoplasmic reticulum |
| Protein Family | TRP (Transient Receptor Potential) channel family, TRPC subfamily |
| Structure | 6 transmembrane domains, tetrameric assembly |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), Stroke |
Trpc1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TRPC1 (Transient Receptor Potential Canonical 1) is the founding member of the TRPC subfamily of non-selective calcium-permeable cation channels. Encoded by the TRPC1 gene, this channel is central to receptor-operated calcium entry and participates in diverse cellular signaling pathways [1][2].
TRPC1 can form homomeric channels or heteromeric assemblies with other TRPC family members (TRPC3, TRPC4, TRPC5, TRPC6, TRPC7), creating channels with distinct properties. The channel is expressed ubiquitously and is essential for normal cellular function [3].
TRPC1 forms tetramers with each subunit containing:
Proline-Rich Domain (PRD)
Ankyrin Repeat Domain
Channel Pore
TRPC1 is a non-selective cation channel:
TRPC1 is activated by:
GPCR Signaling
Store-Operated Mechanisms
Mechanical Stimulation
TRPC1 in AD:
Calcium Dyshomeostasis
Synaptic Impairment
Neuronal Death
In PD:
TRPC1-targeting compounds include:
Antagonists
Activators
The study of Trpc1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.