| TRPC1 — Transient Receptor Potential Cation Channel Subfamily C Member 1 | |
|---|---|
| Symbol | TRPC1 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily C Member 1 |
| Chromosome | 3q23 |
| NCBI Gene | 7220 |
| Ensembl | ENSG00000113615 |
| OMIM | 602409 |
| UniProt | P48995 |
| Diseases | [Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), [Stroke](/diseases/stroke) |
| Expression | Ubiquitous - Brain, Heart, Skeletal muscle, Endothelium |
Trpc1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1) is the founding member of the TRPC (Canonical) subfamily of TRP channels. Located on chromosome 3q23, TRPC1 encodes a non-selective calcium-permeable cation channel that plays fundamental roles in cellular signaling, neuronal function, and vascular homeostasis [1][2].
TRPC1 is ubiquitously expressed and forms both homomeric and heteromeric channels with other TRPC family members. The channel is activated by receptor-operated mechanisms involving phospholipase C (PLC) and is critical for calcium influx in response to G-protein-coupled receptor (GPCR) and tyrosine kinase receptor activation [3][4].
The TRPC1 gene spans approximately 35 kb and consists of 13 exons. It encodes a protein of 793 amino acids with a molecular weight of approximately 90 kDa. The gene promoter contains response elements for various transcription factors, enabling tissue-specific expression [5].
TRPC1 is expressed throughout the nervous system:
TRPC1 functions as a non-selective cation channel with:
TRPC1 is activated through:
G-protein coupled receptors (GPCRs)
Tyrosine kinase receptors
Store-operated mechanisms
In neurons, TRPC1 contributes to:
TRPC1 is implicated in AD through:
Calcium Dysregulation
Synaptic Dysfunction
Neuronal Survival
In PD:
Dopaminergic Neuron Vulnerability
Oxidative Stress
Alpha-Synuclein Toxicity
TRPC1 plays roles in:
TRPC1 is a potential therapeutic target:
Modulators
Signaling Pathway Targets
The study of Trpc1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.