TGF-β Receptor 2 (TGFBR2) is a transmembrane serine/threonine kinase that serves as the primary type II receptor for transforming growth factor-beta ligands in the nervous system. This protein plays critical roles in initiating TGF-β signaling that regulates neuroinflammation, neuronal survival, synaptic plasticity, and glial function.
TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a 70 kDa transmembrane receptor kinase that initiates TGF-β signaling by binding TGF-β ligands and phosphorylating type I receptors (TGFBR1)[1]. As the primary type II receptor, TGFBR2 is constitutively active and essential for all downstream TGF-β signaling in the nervous system[2].
| Attribute | Value |
|---|---|
| Protein Name | TGF-β Receptor 2 |
| Gene Symbol | TGFBR2 |
| UniProt ID | P37173 |
| Molecular Weight | 70 kDa |
| Protein Length | 565 amino acids |
| PDB Structures | 1M9X, 2B3H, 2PJY, 3K70 |
| Subcellular Localization | Plasma membrane, endosomes |
The extracellular domain contains:
Single-pass alpha-helical transmembrane domain anchors the receptor in the plasma membrane.
The cytoplasmic serine/threonine kinase domain contains:
The study of Tgf Β Receptor 2 (Tgfbr2) Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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