TGFBR2 (Transforming Growth Factor Beta Receptor 2) is an essential component of TGF-beta signaling in the nervous system. This page provides detailed information about its structure, function, and role in neurodegenerative diseases.
TGFBR2 (Transforming Growth Factor Beta Receptor 2) encodes the transmembrane serine/threonine kinase receptor that initiates TGF-beta signaling in the central nervous system[1][2]. As the primary type II receptor for TGF-beta ligands, TGFBR2 plays critical roles in regulating neuroinflammation, neuronal survival, synaptic plasticity, and glial cell function[3].
| Attribute | Value |
|---|---|
| Official Symbol | TGFBR2 |
| Official Full Name | Transforming Growth Factor Beta Receptor 2 |
| Chromosomal Location | 3p24.1 |
| NCBI Gene ID | 7048 |
| OMIM | 190182 |
| Ensembl ID | ENSG00000163513 |
| UniProt ID | P37173 |
TGFBR2 is a transmembrane receptor kinase consisting of:
TGFBR2 is constitutively active and transphosphorylates TGFBR1 (type I receptor) upon TGF-beta ligand binding[4].
TGFBR2 is expressed throughout the brain:
The study of Tgfbr2 — Transforming Growth Factor Beta Receptor 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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